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Frequently Used Services
eIRB
eIRB is the IRB online submission system and e-application. Submission to the Penn IRB requires regular utilization of this website in conjunction with using eIRB.
How to Submit
This section describes the logistics and requirements for each type of IRB submission. Review instructions and associated guidance prior to creating your submission in eIRB.
Single IRB Requests to Rely
Click for guidance on how to ask Penn to rely on an external IRB or serve as the single IRB of Record (sIRB).
Treatment Use with an Investigational Agent
When a patient has a serious or life-threatening condition that is not addressed by current approved treatments, options may exist to use an investigational drug or device to treat. The use of an investigational product outside of a clinical trial for treatment of a patient is called “expanded access.” Click below for detailed submission guidance.
Frequently Asked Questions
Click below for FAQs about eIRB, IRB review & submission requirements, required CITI training, and more!
Education
Click below for information about training required to conduct human subjects research at Penn as well as curated educational sessions offered by the Penn IRB to guide members of the research community with their submissions and the conduct of human subjects research.
Upcoming Events
The Latest News from IRB
Sep 4, 2026 @ 10:18 AM
Launch of Penn’s new imaging radiation safety modules and important outage dates for the Novelution platformWe wanted to bring to your attention the launch of Penn’s new Imaging & Radiation Safety modules, which bring the Radiation Research Safety Committee (RRSC), CAMRIS, CT Center, and Nuclear Medicine (NUC Med) review processes into Penn’s eIRB Platform, replacing the current REDCap-based forms. Radiation- and imaging-specific responses within the IRB application will provide researchers with in-line guidance and direct them to the appropriate RRSC, CAMRIS, and/or CT Center application, while NUC Med review will be initiated through the Radiation Safety/RRSC process when applicable. The new modules remain connected to the associated IRB study, carry forward IRB study permissions, and provide reviewers with relevant IRB information, including Informed Consent information, directly within their review. Researchers will be able to view and track associated Imaging & Radiation Safety records and respond to committee feedback from their eIRB Platform Dashboard, while Penn’s existing IRB ancillary review and committee sign-off process will continue alongside these new committee-specific workflows.
The Imaging & Radiation Safety modules will go live later this month, resulting in temporary outages on the Novelution platform. The Penn Production environment will be down during non-standard update hours on Sunday, September 20, 2026, from 10:00 pm to 11:00 pm. Configurations will follow starting Sunday, September 20, 2026, at 11:00 pm through Monday, September 21, at 5:00 am. Normal operations will resume at 5:00 am ET.
Jul 29, 2026 @ 4:44 PM
Resolved eIRB IssuesJul 27, 2026 @ 4:47 PM
Summer 2026 Education SeriesNeed Assistance?
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